The Combined Influence of Oral Contraceptives and Human Papillomavirus Virus on Cutaneous Squamous Cell Carcinoma

The vast majority of cutaneous squamous cell carcinoma (CSCC) will occur in those with fair complexion, tendency to burn, and high ultraviolet radiation (UVR) exposure. Organ transplant recipients also are an important population at great risk for CSCC. An association has been reported between oral contraceptive (OC) use, human papillomavirus virus (HPV) and cervical cancer, and there could be a similar association for CSCC. The cutaneous HPV β-E6 protein, a close cousin of the transformative E6 protein underlying anogenital cancers, has been shown to inhibit apoptosis in response to UVR damage and stimulate morphologic transformation in rodent fibroblast cell lines. Furthermore, OC use has been shown to enhance HPV transcription and may contribute to CSCC risk through this pathway

Ultrastructure du complexe tonofilaments-desmosomes: contribution à l'étude de l'adhésion épidermique

Doctorat en sciences médicalesinfo:eu-repo/semantics/nonPublishe

Topical antibiotic treatment of primary and secondary skin infections with mupirocin

SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Renewal and differentiation of keratinocytes cultured on dead de-epidermalized dermis

SCOPUS: ar.jFLWNAinfo:eu-repo/semantics/publishe

Determination of pesticides and persistent organic pollutants in Italian organic honeys with accelerated solvent extraction and GC-MS/MS

Bee products, such as honey, are widely consumed as food and consumer interest is currently oriented towards organic foods. Regarding this, the European Commission establishes that the qualification of organic honey and other beekeeping products as being from organic production is closely bound with the characteristics of hive treatments as well as the quality of the environment. Agricultural contamination with pesticides is a challenging problem that needs to be fully addressed, in particular in the field of organic production systems. In this study, the occurrence of different classes of contaminants selected as representative of potential contamination sources were investigated in 59 organic honeys [organochlorines (OCs), organophosphates (OPs), polychlorobiphenyls (PCBs) and polybromodiphenylethers (PBDEs)]. A method based on Accelerated Solvent Extraction with \u201cin-line\u201d clean-up and GC-MS/MS detection was developed to detect contaminants. Residues of many pesticides were found in most of the samples investigated. The majority of honey samples contained at least one of the pesticides, even if their concentrations were found to be lower than its MRL. Diazinon, Mevinphos, Coumaphos, Chlorpyrifos and Quinoxyfen were the residues frequently detected in samples coming from the apple and citrus orchard areas. Furthermore, the results of the present study show that the presence of the residue in organic honey may also be affected by the geographical area (e.g. the presence of an agricultural system) confirming honey bee and beehive matrices as appropriate sentinels for monitoring contamination in the environment. The optimised method proved to be simple and rapid, requiring small sample sizes and minimising solvent consumption, due to the ASE having an \u201cin line\u201d clean-up step